09 novembro, 2009

Tamiflu suspensão oral: estabilidade após manipulação

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Tamiflu Oral Suspension (Acacia Syrup) 12 mg/mL 15 mg/mL

Tamiflu (as 75-mg capsules) 1.2 g (16 capsules) 1.5 g (20 capsules)
Acacia Syrup qs 100 mL qs 100 mL

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Tamiflu Oral Suspension (1% Methylcellulose Solution) 12 mg/mL 15 mg/mL

Tamiflu (as 75-mg capsules) 1.2 g (16 capsules) 1.5 g (20 capsules)
Methylcellulose 1% Solution qs 100 mL qs 100 mL


Stability of the above formulations:

Refrigeration: Stable for 90 days when stored in a refrigerator at 2°C to 8°C (36°F to 46°F).

Room Temperature: Stable for 90 days when stored at room temperature (25°C; 77°F).

References: Loyd V. Allen, Jr., PhD, RPh